Please click to visit San Ramon Regional Medical Center

NoBlood Answers

ASK questions regarding Transfusion Alternatives and Patient Blood Management.

SHARE your facts, opinions and personal experience.

DISCOVER the best answers chosen by Healthcare Professionals and the Public.

RANK the best answers.

199 questions

265 answers


75 users

Popular Tags

treatmentsx 54  conditionsx 36  pharmaceuticalsx 19  transfusionsx 19  bloodx 18  anemiax 16  alternativesx 13  epox 13  devicesx 10  managementx 10  documentsx 9  dpax 8  legalx 8  fractionsx 7  ironx 7  plateletsx 7  techniquesx 7  cancerx 6  coagulationx 6  dphcx 6  hospitalsx 6  outcomesx 6  preparationx 6  surgeryx 6  toolsx 6  cardiacx 5  cell-salvagex 5  dietx 5  hemodilutionx 5  leukemiax 5  programsx 5  vaccinesx 5  diagnosisx 4  hbocx 4  plasmax 4  proteinx 4  testingx 4  transplantsx 4  volume-expandersx 4  bloodlessx 3  esax 3  fibrin-gluex 3  financialx 3  formsx 3  guidelinesx 3  hemoglobinx 3  hemorrhagex 3  hemostasisx 3  hepatitis-cx 3  immunoglobulinx 3  lungx 3  oxygenx 3  pregnancyx 3  surgicalx 3  syntheticx 3  acidx 2  adhesivesx 2  amlx 2  bleedingx 2  carriersx 2  chemotherapyx 2  chlorophyllx 2  cllx 2  cmmlx 2  creutzfeldt-jakobx 2  diptheriax 2  diseasesx 2  doctorsx 2  factor-7x 2  heartx 2  jcahox 2  liverx 2  pediatricx 2  preemiex 2  proceduresx 2  procritx 2  rbcx 2  sickle-cellx 2  studiesx 2  surgeonsx 2  tetanusx 2  thalassemia-majorx 2  tranexamicx 2  transmissionx 2 

More Tags

What is Creutzfeldt-Jakob disease and how is it transmitted?

0 like 0 dislike
asked May 8, 2012 in Glossary by Hatice Simsek MD (3,070 points)
retagged Jun 4, 2012 by LarryEitel

1 Answer

0 like 0 dislike

Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. It affects about one person in every one million people per year worldwide; in the United States there are about 200 cases per year. CJD usually appears in later life and runs a rapid course. Typically, onset of symptoms occurs about age 60, and about 90 percent of individuals die within 1 year. In the early stages of disease, people may have failing memory, behavioral changes, lack of coordination and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur.

There are three major categories of CJD:

  • In sporadic CJD, the disease appears even though the person has no known risk factors for the disease. This is by far the most common type of CJD and accounts for at least 85 percent of cases.
  • In hereditary CJD, the person has a family history of the disease and/or tests positive for a genetic mutation associated with CJD. About 5 to 10 percent of cases of CJD in the United States are hereditary.
  • In acquired CJD, the disease is transmitted by exposure to brain or nervous system tissue, usually through certain medical procedures. There is no evidence that CJD is contagious through casual contact with a CJD patient. Since CJD was first described in 1920, fewer than 1 percent of cases have been acquired CJD.

CJD belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (TSEs). Spongiform refers to the characteristic appearance of infected brains, which become filled with holes until they resemble sponges under a microscope. CJD is the most common of the known human TSEs. Other human TSEs include kuru, fatal familial insomnia (FFI), and Gerstmann-Straussler-Scheinker disease (GSS). Kuru was identified in people of an isolated tribe in Papua New Guinea and has now almost disappeared. FFI and GSS are extremely rare hereditary diseases, found in just a few families around the world. Other TSEs are found in specific kinds of animals. These include bovine spongiform encephalopathy (BSE), which is found in cows and is often referred to as “mad cow” disease; scrapie, which affects sheep and goats; mink encephalopathy; and feline encephalopathy. Similar diseases have occurred in elk, deer, and exotic zoo animals.


Notice that this is Not vCJD!

answered May 9, 2012 by pnutts (1,820 points)

The interesting point it that article is: 


Many people are concerned that it may be possible to transmit CJD through blood and related blood products such as plasma. Some animal studies suggest that contaminated blood and related products may transmit the disease, although this has never been shown in humans. If there are infectious agents in these fluids, they are probably in very low concentrations. Scientists do not know how many abnormal prions a person must receive before he or she develops CJD, so they do not know whether these fluids are potentially infectious or not. They do know that, even though millions of people receive blood transfusions each year, there are no reported cases of someone contracting CJD from a transfusion. Even among people with hemophilia, who sometimes receive blood plasma concentrated from thousands of donors, there are no reported cases of CJD.

While there is no evidence that blood from people with sporadic CJD is infectious, studies have found that infectious prions from BSE and vCJD may accumulate in the lymph nodes (which produce white blood cells), the spleen, and the tonsils. These findings suggest that blood transfusions from people with vCJD might transmit the disease. The possibility that blood from people with vCJD may be infectious has led to a policy preventing people in the United States from donating blood if they have resided for more than 3 months in a country or countries where BSE is common.`

Related questions


Featured Sponsors