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What Role do Platelets Play in the Human Body and How Does Clotting Take Place?

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asked May 30, 2012 in Conditions and Treatments by Jan B. Wade (4,930 points)
edited May 30, 2012 by Jan B. Wade

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Platelets have two hemostatic (cessation of bleeding by means of coagulation) functions: (1) the form a platelet plug over the area of a wound, and (2) they provide platelet factor-3 which makes it possible for clotting factors to become active which is essential for a blot clot to form to stop a wound from bleeding.  Hemostasis is a four-step process which includes: (1) vascular spasm, (2) platelet plug formation, (3) coagulation factor activation, and (4) lysis, or the breakdown of the fibrin clot.  When you cut yourself there is an extremely intricate process that goes on to stop the bleeding.  About 13 clotting factors are "signaled" to cascade to the wound site and the final closure by the platelets cause a platelet plug.  Through the wound healing process, molecules and cells trapped within the clot begin to repair the damaged wound site.  Once the area is repaired the process of breaking up the fibrin clot takes place and blood flow resumes.
answered Jun 4, 2012 by jlvarisco (2,070 points)
selected Mar 12, 2016 by Jan B. Wade

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