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What is SD plasma?

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My doctor advises plasma exchange. I refused FFP and he asked if I'd accept SD plasma or cryo-depleted plasma. What are these products?
asked Jul 6, 2012 in Conditions and Treatments by anonymous
retagged Jul 6, 2012 by LarryEitel

3 Answers

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PLAS+SD is pooled plasma treated with solvent detergent.

Here is a link to an iTransfuse Fact Sheet that explains cryo-depleted plasma.  It includes an explaination of it's use and how it is produced:

http://www.transfusion.com.au/sites/default/files/iTRANSFUSE%202.7%20CRYO%20DEPLETED%20PLASMA.pdf

Both products are basically plasma, just treated differently.
answered Jul 6, 2012 by anonymous
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Blood Transfus. 2007 July; 5(3): 134–142.

Virus-inactivated plasma - Plasmasafe: a one-year experience

 

...SD virus-inactivated plasma (SD-plasma) is fresh-frozen plasma (FFP) derived from pooled plasma (up to 2,500 blood donors), treated using the solvent Tris (n-butyl)phosphate and the detergent Triton X-100. This treatment effectively inactivates lipid-enveloped viruses, namely HIV-1/2, HCV, HBV, and HTLV-I/II, but has no effect on non-enveloped viruses, including HAV and Parvovirus B19, or on prions. SD treatment can induce a reduction of procoagulant factors, although their levels remain within the normal range. Moreover, it has been discovered in the USA that, unlike FFP, SD-plasma does not cause a post-transfusion increase of protein S (PS), and produces a reduction of the plasminogen inhibitor: however, the SD-inactivation procedure applied in the USA is different from the one used in Europe, as the process involves an ultrafiltration step, which decreases the plasma concentrations of alpha-1-antitrypsin, alpha-2-antiplasmin and PS 710. ...

 

 

answered Jul 9, 2012 by Hatice Simsek MD (3,070 points)
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SD treated plasma are the liquid part of the blood that was treated with solvent and detergent to kill viruses like

hepatitis , aids viruses and other blood pathogens . All solvents and detergent used to treat the blood component

are eliminated completely making the blood component very safe some life threatening conditions. I am not sure

if SD treated plasma are available here in the US, they are available in UK . NY Blood center used to be the best

source for SD plasma.
answered Aug 28, 2013 by anonymous

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