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What is Cryosupernatant? How is it used? Is it basically cyro-poor plasma?

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I was asked this question by someone- not sure how to answer.
asked Jul 18, 2012 in Conditions and Treatments by pnutts (1,820 points)

4 Answers

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I think the word you are looking for is cryoprecipitate
answered Jul 18, 2012 by anonymous

 it is

Cryosupernatant not cryoprecipitate.

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It is indeed cryprecipitate reduced....

Cryosupernatant is the product that remains when Fresh Frozen Plasma is processed to make cryoprecipitate.  It contains plasma proteins and all of the other clotting factors (including II, VII, IX, and X).  It can be used for all of the same indications as FFP except for Hemophilia A and von Willebrand’s disease.  It is particularly useful for coagulopathies such as warfarin poisoning and Hemophilia B (Factor IX deficiency).


Key Benefits

bullet Typed for DEA 1.1 Negative or DEA 1.1 Positive -  type unspecific when cell contamination is less than 2%
bullet Treats sepsis
bullet Beneficial for warfarin (rat) poisoning


Whole Unit -  components produced from 450 ml of whole blood

Half Unit - components produced from 250 ml of whole blood

How is it produced?  See Here

answered Jul 18, 2012 by Jan B. Wade (4,930 points)
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Cryosupernatant: plasma from which cryoprecipitate has been removed

answered Jul 18, 2012 by Hatice Simsek MD (3,070 points)
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Cryosupernatant as replacement fluid for plasma exchange in thrombotic thrombocytopenic purpura

British Journal of Haematology

Volume 94Issue 2pages 383–386August 1996


The current established treatment of thrombotic thrombocytopenic purpura (TTP) is plasma exchange with fresh frozen plasma (FFP). With this treatment, there is a 49% response after seven exchanges and a 78% survival at 1 month. Although the exact cause of TTP is unknown, the presence of von Willebrand factor (VWF) multimers has been implicated in the disease. Accordingly, it has been suggested that cryosupernatant (plasma from which cryoprecipitate has been removed), which is relatively deficient in VWF multimers, might be an effective replacement fluid during plasma exchange.

Patients from six centres were treated by plasma exchange with cryosupernatant. 18 patients who had failed a first course (average 7.7 exchanges) of plasma exchange with FFP, received a further seven exchanges with cryosupernatant. Subsequently, 40 previously untreated patients were exchanged with cryosupernatant.

Of the 18 previously treated patients, 11 responded (defined as an increase in platelet count to >150 × 109/l and no neurological events) after seven exchanges and 15 (83%) of the patients were alive at 1 month. The response rate in the 40 previously untreated patients was 75% at the end of seven exchanges and 95% of the patients were alive at 1 month. These values are significantly different (P<0.05) from those reported in our earlier study and in other patients concurrently treated at the same centres with FFP when cryosupernatant was not available.

Some patients who have failed to respond to plasma exchange with FFP replacement will respond to further exchange with cryosupernatant. Cryosupernatant replacement may be more effective as first-line treatment of TTP than FFP.


answered Jul 18, 2012 by Hatice Simsek MD (3,070 points)

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