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difference between erythropoietin and darbepoietin? Is there an advantage to one over the other?

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asked Dec 10, 2012 in Site Q&A by martyj2 (140 points)
Erythropoietin acts more quickly in the stimulation of the bone marrow.  Darbepoietin is used mostly in kidney dialysis patients and is more time released throughout the body.

Depending upon the country you are in, darbepoietin is stabilized with albumin, but it can be especially ordered without the albumin, which is a fractionated protein of plasma.

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yes there are differences between ESA's erythropoiesis-stimulating agents such as EPO ( Procrit and 2 others made by Amgen, there are other brands ) and Darbepoetin.

The Oncologist quote "The four currently available erythropoiesis-stimulating agents (ESAs), the main drugs for correcting anemia in
patients with chronic kidney disease (CKD), are epoetin alfa, epoetin beta, darbepoetin alfa, and continuous erythropoietin receptor activator. " unquote

Darbepoetin is not stabalized with a blood fraction as many EPO's are and unfortunately - although having a longer shelf-life -Darbepoetin does seem to more adverse reactions.

It behooves one to research which ESA's are available in your country - which brands are available locally and what your choices is.
answered Dec 13, 2012 by pnutts (1,820 points)

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