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Thread: What exactly is "serum-derived immunoglobulin antibodies and immuno-proteins"?

  1. #1
    Registered User
    Join Date
    Feb 2007

    What exactly is "serum-derived immunoglobulin antibodies and immuno-proteins"?


    My son was prescribed a supplement for acid reflux and immune system improvement.
    It is from XYMOGEN (, and the product is IgG 2000 DF--Proprietary Immunoglobulin Concentrate High Potency lgG. Pharmaceutical Grade Professional Use Only.
    Label says:

    IgG 2000 DF (TM) represents a breakthrough in immunoglobulin supplementation. it is a highly concentrated, non-dairy source of serum-derived immunoglobulin antibodies and immuno-proteins. It possesses 3 times more IgG and total immunoglobulins than colostrum and has twice as much cysteine, an important amino acid for maintaining glutathione levels.
    IgG 2000 DF (TM) delivers 15 times the level of transferrin and lactoferrin than colostrum alone and one therapeutic dose of IgG 2000 DF (TM) supplies over 2000 mg of IgG.

    Supplement Facts:

    IgG 2000 DF (TM) 1250 mg
    (serum derived immunoglobulin concentrate providing IgG, IgA, IgM, IgE, IgD. Also provides Transferrins, IGF-1 and TGFB-1

    Immunoglobulin G (IgG 562.5 mg
    (from 1250 mg IgG (IgG)


    I am interested in from what source this is taken (I assume not bovine), what exactly this includes and truthfully why would this be needed by a toddler (as proscribed by a Naturapath)?

    Also, what possible harm could this include from the serum it was derived from (diease, other blood factors)?

    Thank you for any assistance you can provide.



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  3. #2
    Good questions. The product description is a bit misleading (when we read "dairy-free" we might assume cows not involved), but the manufacturer's PDF does mention that is is bovine. So, it's obtained from cow blood -- not cow milk. It's a tiny fraction of blood.

    Orally-administerd IgG one might think would be broken down into amino acids by stomach acids and pancreatic enzymes, but it does seem (like colostrum, transfer factor, etc) to carry health benefits -- as the reputable references in the PDF attest.

    The risks associated would be comparable, I think, to eating a medium-rare steak -- which probably contains trace amounts of intact bovine IgG.

    Acid reflux, leaky-gut, eczema, and weak-immune systems are reaching epidemic proportions in babies. Conventional approaches (Zantac, Nexium, antibiotics, etc) don't have much success. More parents are turning to naturopathic options such as probiotics, vitamins, and oral IgG.

    But these doctors should be aware that this is a blood-derived product, and that info is important for parents to know up-front.
    Joseph T. Malak, MD

  4. #3
    Registered User
    Join Date
    Jun 2011
    I am interested in this as well! Thanks for posting this question!

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